Acerbi, Francesco and Restelli, Francesco and de Laurentis, Camilla and Falco, Jacopo and Cavallo, Claudio and Broggi, Morgan and Hoehne, Julius and Schebesch, Karl-Michael and Schiariti, Marco and Ferroli, Paolo (2021) Fluorescent tracers in neurosurgical procedures: a European survey. JOURNAL OF NEUROSURGICAL SCIENCES, 65 (6). pp. 618-625. ISSN 0390-5616, 1827-1855
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: In recent years several techniques have been proposed with the aim of improving tumors visualization and extent of resection and, among them, the use of photosensitive dyes is gaining great interest. Regarding the application of the two most used dyes, 5-aminolevulinic acid (5-ALA) and sodium fluorescein (SF), there is still a lack of shared and established protocols among different centers. The main objective of the present study was to evaluate the current practice of fluorescence-guided techniques in neuro-oncological surgery in Europe. METHODS: An online questionnaire consisting of 33 questions was completed by 136 European Association of Neurosurgical Societies neurosurgeons. Responses were entered into a database and subsequently analyzed. RESULTS: Data were analyzed from 136 out of 1476 active European neurosurgeons which had been contacted, with a 9,2% response rate. Based on the data from the questionnaire, Germany was the most responsive country (15% of the total respondents) and the main indication for 5-ALA and SF utilization were high-grade gliomas. 5-ALA was mainly used as defined in Gliolan (R) datasheet, while SF as off-label technique with a 5 mg/kg dose of injection at the end of patient intubation. Both the dyes were mainly used in adult population, more frequently by neurosurgeons with less-than 20 cases per year expertise. Mean price per patient were 817,6 (sic) and 7,7 (sic) for 5-ALA and SF, respectively. CONCLUSIONS: 5-ALA acid is still the preferred and more established fluorescent dye used during high-grade gliomas resection, with SF as a gaining-attention, really cheaper and more ductile alternative.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-GRADE GLIOMAS; GUIDED SURGERY; 5-AMINOLEVULINIC ACID; MALIGNANT GLIOMAS; PHASE-III; RESECTION; BRAIN; GLIOBLASTOMA; ANGIOGRAPHY; Aminolevulinic acid; Fluorescein; Glioma; Survey and questionnaires |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Abteilung für Neuropathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Sep 2022 05:01 |
| Last Modified: | 05 Sep 2022 05:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46487 |
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