Proescholdt, Martin and Junger, Stephanie T. and Schodel, Petra and Schebesch, Karl-Michael and Doenitz, Christian and Pukrop, Tobias and Hohne, Julius and Schmidt, Nils-Ole and Kocher, Martin and Schulz, Holger and Ruge, Maximilian and Konig, Kevin and Goldbrunner, Roland and Grau, Stefan (2021) Brain Metastases in Elderly Patients-The Role of Surgery in the Context of Systemic Treatment. BRAIN SCIENCES, 11 (1): 123. ISSN , 2076-3425
Full text not available from this repository. (Request a copy)Abstract
In patients with brain metastases (BM), advanced age is considered a negative prognostic factor. To address the potential reasons for that, we assessed 807 patients who had undergone BM resection; 315 patients aged at least 65 years (group A) were compared with 492 younger patients (group B). We analyzed the impact of the pre- and postoperative Karnofsky performance status (KPS), postoperative treatment structure and post-treatment survival. BM resection significantly improved KPS scores in both groups (p = 0.0001). Median survival after BM resection differed significantly between the groups (A: 5.81 vs. B: 8.12 months; p = 0.0015). In both groups, patients who received postoperative systemic treatment showed significantly longer overall survival (p = 0.00001). However, elderly patients less frequently received systemic treatment (p = 0.0001) and the subgroup of elderly patients receiving such therapies had a significantly higher postsurgical KPS score (p = 0.0007). In all patients receiving systemic treatment, age was no longer a negative prognostic factor. Resection of BM improves the functional status of elderly patients, thus enhancing the likeliness to receive systemic treatment, which, in turn, leads to longer overall survival. In the context of such a treatment structure, age alone is no longer a prognostic factor for survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Brain metastases; elderly patients; targeted therapy; survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Sep 2022 06:08 |
| Last Modified: | 05 Sep 2022 06:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46519 |
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