Markowiak, Till and Ried, Michael and Larisch, Christopher and Nowak, Dennis and Hofmann, Hans-Stefan and Rakete, Stefan (2022) Exposure to cisplatin in the operating room during hyperthermic intrathoracic chemotherapy. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 95 (2). pp. 399-407. ISSN 0340-0131, 1432-1246
Full text not available from this repository. (Request a copy)Abstract
Purpose Hyperthermic intrathoracic chemotherapy (HITOC) is an additive, intraoperative treatment for selected malignant pleural tumors. To improve local tumor control, the thoracic cavity is perfused with a cisplatin-containing solution after surgical cytoreduction. Since cisplatin is probably carcinogenic to humans, potential contamination of surfaces and pathways of exposure should be systematically investigated to enable risk assessments for medical staff and thus derive specific recommendations for occupational safety. Methods Wipe sampling was performed at pre-selected locations during and after ten HITOC procedures, including on the surgeon's gloves, for the quantitation of surface contaminations with cisplatin. After extraction of the samples with hydrochloric acid, platinum was determined as a marker for cisplatin by voltammetry. Results High median concentrations of cytostatic drugs were detected on the surgeons' (1.73 pg Cis-Pt/cm(2), IQR: 9.36 pg Cis-Pt/cm(2)) and perfusionists' (0.69 pg Cis-Pt/cm(2), IQR: 1.73 pg Cis-Pt/cm(2)) gloves. The display of the perfusion device showed partially elevated levels of cisplatin up to 4.92 pg Cis-Pt/cm(2) and thus could represent an origin of cross-contamination. In contrast, cisplatin levels on the floor surfaces in the area of the surgeon and the perfusion device or in the endobronchial tube were relatively low. Conclusion With a correct use of personal protective equipment and careful handling, intraoperative HITOC appears to be safe to perform with a low risk of occupational exposure to cisplatin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTINEOPLASTIC DRUGS; SURFACE CONTAMINATION; HOSPITAL PERSONNEL; PHARMACY; AGENTS; MESOTHELIOMA; SURGERY; WORKERS; URINE; Hyperthermic intrathoracic chemotherapy; HITOC; Cisplatin; Surface contamination; Occupational exposure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Thoraxchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Sep 2022 08:11 |
| Last Modified: | 05 Sep 2022 08:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46591 |
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