Schimp, Julia and Dornia, Christian and Fanghanel, Jochen and Proff, Peter and Blanck-Lubarsch, Moritz and Weingartner, Jens and Kirschneck, Christian (2021) Morphometric characteristics of anencephalic skulls - A comparative study. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 233: 151607. ISSN 0940-9602, 1618-0402
Full text not available from this repository. (Request a copy)Abstract
Anencephaly is the most severe form of a neural tube defect resulting from the incomplete occlusion of the anterior neuropore in the fourth week of development and associated with a severely underdeveloped brain mass. As desmal ossification of the neurocranium is induced by the presence of soft tissues (brain), no bone develops as direct consequence of the missing brain. The cranial base, by contrast, is formed by chondral ossification, which is genetically determined, and thus present also in anencephaly. Morphometric characteristics of anencephalic skulls, however, have not yet been investigated in sufficient detail before. In this study we therefore comparatively assessed macroscopic morphological-anatomical and cephalometric CT data on structures and dimensions of 11 macerated anencephalic and 4 normal neonatal skulls highlighting skeletal morphological differences. The most striking results were the missing skullcap and the greatly changed morphology of the existing skull bones, which were reduced in size. The parameters of the skull base, the transverse orbital diameter and maxillary width were significantly smaller in anencephalic skulls. The morphology of the viscerocranium appeared similar to that of normal neonatal skulls. The results of this study can be used in diagnosis and skeletal classification for anencephaly. This can help identify bones that are incomplete, fragmented and taphonomically altered, which is often the case in historical and forensic studies. (C) 2020 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEURAL-TUBE DEFECTS; HUMAN FETUSES; CLEFT-LIP; DIAGNOSIS; FETAL; MORPHOLOGY; SPECTRUM; PALATE; Anencephaly; Neural tube defects; Cephalometry; Bone abnormalities; Cranial defects |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Sep 2022 06:45 |
| Last Modified: | 06 Sep 2022 06:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46643 |
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