Watzlowik, Maria Theresia and Das, Sujaan and Meissner, Markus and Laengst, Gernot (2021) Peculiarities of Plasmodium falciparum Gene Regulation and Chromatin Structure. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (10): 5168. ISSN 1422-0067
Full text not available from this repository. (Request a copy)Abstract
The highly complex life cycle of the human malaria parasite, Plasmodium falciparum, is based on an orchestrated and tightly regulated gene expression program. In general, eukaryotic transcription regulation is determined by a combination of sequence-specific transcription factors binding to regulatory DNA elements and the packaging of DNA into chromatin as an additional layer. The accessibility of regulatory DNA elements is controlled by the nucleosome occupancy and changes of their positions by an active process called nucleosome remodeling. These epigenetic mechanisms are poorly explored in P. falciparum. The parasite genome is characterized by an extraordinarily high AT-content and the distinct architecture of functional elements, and chromatin-related proteins also exhibit high sequence divergence compared to other eukaryotes. Together with the distinct biochemical properties of nucleosomes, these features suggest substantial differences in chromatin-dependent regulation. Here, we highlight the peculiarities of epigenetic mechanisms in P. falciparum, addressing chromatin structure and dynamics with respect to their impact on transcriptional control. We focus on the specialized chromatin remodeling enzymes and discuss their essential function in P. falciparum gene regulation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN MALARIA PARASITE; TRANSCRIPTION START SITES; DNA-SEQUENCE; NUCLEOSOME LANDSCAPE; COMPARATIVE GENOMICS; REMODELING HOMOLOG; INTERGENIC REGIONS; VIRULENCE GENES; NONCODING RNAS; REVEALS; chromatin; epigenetics; Plasmodium falciparum; nucleosome; nucleosome remodeling; transcription regulation; chromatin structure |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst |
| Depositing User: | Petra Gürster |
| Date Deposited: | 10 Jan 2023 11:01 |
| Last Modified: | 10 Jan 2023 11:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46698 |
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