McKenna, Mary Clare and Tahedl, Marlene and Lope, Jasmin and Chipika, Rangariroyashe H. and Li Hi Shing, Stacey and Doherty, Mark A. and Hengeveld, Jennifer C. and Vajda, Alice and McLaughlin, Russell L. and Hardiman, Orla and Hutchinson, Siobhan and Bede, Peter (2022) Mapping cortical disease-burden at individual-level in frontotemporal dementia: implications for clinical care and pharmacological trials. BRAIN IMAGING AND BEHAVIOR, 16. pp. 1196-1207. ISSN 1931-7557, 1931-7565
Full text not available from this repository. (Request a copy)Abstract
Imaging studies of FTD typically present group-level statistics between large cohorts of genetically, molecularly or clinically stratified patients. Group-level statistics are indispensable to appraise unifying radiological traits and describe genotype-associated signatures in academic studies. However, in a clinical setting, the primary objective is the meaningful interpretation of imaging data from individual patients to assist diagnostic classification, inform prognosis, and enable the assessment of progressive changes compared to baseline scans. In an attempt to address the pragmatic demands of clinical imaging, a prospective computational neuroimaging study was undertaken in a cohort of patients across the spectrum of FTD phenotypes. Cortical changes were evaluated in a dual pipeline, using standard cortical thickness analyses and an individualised, z-score based approach to characterise subject-level disease burden. Phenotype-specific patterns of cortical atrophy were readily detected with both methodological approaches. Consistent with their clinical profiles, patients with bvFTD exhibited orbitofrontal, cingulate and dorsolateral prefrontal atrophy. Patients with ALS-FTD displayed precentral gyrus involvement, nfvPPA patients showed widespread cortical degeneration including insular and opercular regions and patients with svPPA exhibited relatively focal anterior temporal lobe atrophy. Cortical atrophy patterns were reliably detected in single individuals, and these maps were consistent with the clinical categorisation. Our preliminary data indicate that standard T1-weighted structural data from single patients may be utilised to generate maps of cortical atrophy. While the computational interpretation of single scans is challenging, it offers unrivalled insights compared to visual inspection. The quantitative evaluation of individual MRI data may aid diagnostic classification, clinical decision making, and assessing longitudinal changes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AMYOTROPHIC-LATERAL-SCLEROSIS; BEHAVIORAL VARIANT; DIAGNOSTIC CLASSIFICATION; TISSUE PATHOLOGY; ALS VALIDATION; FDG-PET; SENSITIVITY; SIGNATURES; CRITERIA; BIOMARKERS; Frontotemporal dementia; Cerebellum; PPA; Behaviour; MRI; Cortical thickness |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Human Sciences > Institut für Psychologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Nov 2024 10:38 |
| Last Modified: | 07 Nov 2024 10:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46712 |
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