Delacher, Michael and Simon, Malte and Sanderink, Lieke and Hotz-Wagenblatt, Agnes and Wuttke, Marina and Schambeck, Kathrin and Schmidleithner, Lisa and Bittner, Sebastian and Pant, Asmita and Ritter, Uwe and Hehlgans, Thomas and Riegel, Dania and Schneider, Verena and Groeber-Becker, Florian Kai and Eigenberger, Andreas and Gebhard, Claudia and Strieder, Nicholas and Fischer, Alexander and Rehli, Michael and Hoffmann, Petra and Edinger, Matthias and Strowig, Till and Huehn, Jochen and Schmidl, Christian and Werner, Jens M. and Prantl, Lukas and Brors, Benedikt and Imbusch, Charles D. and Feuerer, Markus (2021) Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. IMMUNITY, 54 (4). 702-+. ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine and human tissue Treg cells defined a conserved, microbiota-independent tissue-repair Treg signature with a prevailing footprint of the transcription factor BATF. This signature, combined with gene expression profiling and TCR fate mapping, identified a population of tissue-like Treg cells in human peripheral blood that expressed BATF, chemokine receptor CCR8 and HLA-DR. Human BATF(+) CCR8(+) Treg cells from normal skin and adipose tissue shared features with nonlymphoid T follicular helper-like (Tfh-like) cells, and induction of a Tfh-like differentiation program in naive human Treg cells partially recapitulated tissue Treg regenerative characteristics, including wound healing potential. Human BATF(+) CCR8(+) Treg cells from healthy tissue share features with tumor-resident Treg cells, highlighting the importance of understanding the context-specific functions of these cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME BROWSER; POPULATION; ALIGNMENT; LINEAGE; BATF; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Sep 2022 09:46 |
| Last Modified: | 06 Sep 2022 09:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46717 |
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