Jobin, Katarzyna and Müller, Dominik N. and Jantsch, Jonathan and Kurts, Christian (2021) Sodium and its manifold impact on our immune system. TRENDS IN IMMUNOLOGY, 42 (6). pp. 469-479. ISSN 1471-4906, 1471-4981
Full text not available from this repository. (Request a copy)Abstract
The Western diet is rich in salt, and a high salt diet (HSD) is suspected to be a risk factor for cardiovascular diseases. It is now widely accepted that an experimental HSD can stimulate components of the immune system, potentially exacerbating certain autoimmune diseases, or alternatively, improving defenses against certain infections, such as cutaneous leishmaniasis. However, recent findings show that an experimental HSD may also aggravate other infections (e.g., pyelonephritis or systemic listeriosis). Here, we discuss the modulatory effects of a HSD on the microbiota, metabolic signaling, hormonal responses, local sodium concentrations, and their effects on various immune cell types in different tissues. We describe how these factors are integrated, resulting either in immune stimulation or suppression in various tissues and disease settings.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-C; OSMOTICALLY INACTIVE NA+; HIGH-SALT DIET; MACROPHAGE POLARIZATION; ANTIBACTERIAL DEFENSE; ANGIOTENSIN-II; STORAGE; SKIN; HYPERTENSION; TISSUE |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 11 Jan 2023 06:25 |
| Last Modified: | 11 Jan 2023 06:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46792 |
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