Mayr, Judith and Bachl, Juergen and Schlossmann, Jens and Diaz Diaz, David (2017) Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18 (2): 303. ISSN 1422-0067,
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A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFECTIOUS-DISEASES-SOCIETY; BAD BUGS; POLYMERS; ANTIBACTERIAL; DISINFECTANT; COPOLYMERS; HYDROGELS; PEPTIDES; AMERICA; IONENES; antimicrobial polymer; ionenes; polycations; quaternary ammonium; hemolysis; topomers |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 27 Feb 2019 12:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/468 |
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