Prantl, Lukas and Moellhoff, Nicholas and von Fritschen, Uwe and Giunta, Riccardo and Germann, Guenter and Kehrer, Andreas and Thiha, Aung and Ehrl, Denis and Zeman, Florian and Broer, Peter Niclas and Heidekrueger, Paul Immanuel (2021) Effect of Radiation Therapy on Microsurgical Deep Inferior Epigastric Perforator Flap Breast Reconstructions A Matched Cohort Analysis of 4577 Cases. ANNALS OF PLASTIC SURGERY, 86 (6). pp. 627-631. ISSN 0148-7043, 1536-3708
Full text not available from this repository. (Request a copy)Abstract
Introduction Breast reconstruction with autologous tissue is a state-of-the art procedure. Several patient-related factors have been identified with regard to the safety and efficacy of these reconstructions. The presented study investigates the impact of prereconstruction radiation on outcomes of deep inferior epigastric perforator (DIEP) free-flap breast reconstructions using largest database available in Europe. Materials and Methods Between 2011 and 2019, 3926 female patients underwent 4577 DIEP flap breast reconstructions in 22 different German breast cancer centers. The cases were divided into a no-radiation (NR) and a radiation (R) group, according to radiation status before reconstruction. Groups were compared with regard to surgical complications and free-flap outcome. Results Overall, there was no significant difference between the groups regarding the rate of total flap loss [1.9% (NR) vs 2.1% (R), P = 0.743], partial flap loss [0.9% (NR) vs 1.5 (R), P = 0.069], and revision surgery [vascular revision: 4.4% (NR) vs 4.1% (R), P = 0.686; wound revision: 7.6% (NR) vs 9.4% (R), P = 0.122]. However, the patients had a significantly higher risk of developing wound healing disturbances at the recipient site [1.2% (NR) vs 2.1% (R), P = 0.035] and showed significantly longer hospitalization {8 [SD, 8.4 (NR)] vs 9 [SD, 15.4 {R}] days, P = 0.006} after prereconstruction radiation. Conclusions Our findings suggest that DIEP flap reconstruction after radiation therapy is feasible. Women with a history of radiation therapy should, however, be informed in detail about the higher risk for wound healing disturbances at the recipient site.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEOADJUVANT CHEMOTHERAPY; ADJUVANT RADIOTHERAPY; MUTATION CARRIERS; CANCER; OUTCOMES; MASTECTOMY; MANAGEMENT; BRCA1; breast reconstruction; DIEP flap; radiation; microsurgery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Sep 2022 11:22 |
| Last Modified: | 07 Sep 2022 11:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46804 |
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