Hoffmann, Rebecca and Ruegamer, Tamara and Schaubaecher, Johanna and Rohrhofer, Anette and Kirmess, Peter and Fiebig, Karen M. and Schmidt, Barbara and Eichler, Jutta (2021) Exploring Viral Interference Using Peptides: Molecular Determinants of HIV-1 Inhibition by a Peptide Derived from Human Pegivirus-1 Envelope Protein E2. CHEMMEDCHEM, 16 (8). pp. 1290-1296. ISSN 1860-7179, 1860-7187
Full text not available from this repository. (Request a copy)Abstract
Co-infection with the human pegivirus 1 (HPgV-1) often has a beneficial effect on disease progression in HIV-1-infected individuals. Several HPgV-1 proteins and peptides, including a 20-mer peptide (P6-2) derived from the N-terminal region of the HPgV-1 surface protein E2, have been associated with this phenomenon, which is referred to as viral interference. We identified the cysteine residues, the hydrophobic core tetrapeptide, as well as the C-terminal negative charge as key factors for the HIV-1 inhibitory activity of P6-2. Analysis of mutations in P6-2-resistant HIV-1 indicated a binding site for the peptide in the HIV-1 envelope glycoprotein gp120. In fact, P6-2 was shown to bind to soluble gp120, as well as to a peptide presenting the gp120 V3 loop. Furthermore, the HIV-1 inhibitory activity of P6-2 could be revoked by the V3 loop peptide, thus indicating a molecular mechanism that involves interaction of P6-2 with the gp120 V3 loop.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; gp120  V3 loop; HIV-1; human pegivirus; peptides; viral interference |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Sep 2022 13:38 |
| Last Modified: | 07 Sep 2022 13:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46831 |
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