Graessel, Susanne and Zaucke, Frank and Madry, Henning (2021) Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology. JOURNAL OF CLINICAL MEDICINE, 10 (9): 1938. ISSN 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes significant health and social problems worldwide, its exact etiology is still unclear. With an aging and increasingly obese population, OA is becoming even more prevalent than in previous decades. Up to 35% of the world's population over 60 years of age suffers from symptomatic (painful, disabling) OA. The disease poses a tremendous economic burden on the health-care system and society for diagnosis, treatment, sick leave, rehabilitation, and early retirement. Most patients also experience sleep disturbances, reduced capability for exercising, lifting, and walking and are less capable of working, and maintaining an independent lifestyle. For patients, the major problem is disability, resulting from joint tissue destruction and pain. So far, there is no therapy available that effectively arrests structural deterioration of cartilage and bone or is able to successfully reverse any of the existing structural defects. Here, we elucidate novel concepts and hypotheses regarding disease progression and pathology, which are relevant for understanding underlying the molecular mechanisms as a prerequisite for future therapeutic approaches. Emphasis is placed on topographical modeling of the disease, the role of proteases and cytokines in OA, and the impact of the peripheral nervous system and its neuropeptides.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-RELATED PEPTIDE; DORSAL-ROOT GANGLIA; MEDIAL MENISCAL EXTRUSION; PERIPHERAL-NERVE FIBERS; MATRIX PROTEIN COMP; KNEE OSTEOARTHRITIS; CARTILAGE LOSS; SUBSTANCE-P; ARTICULAR-CARTILAGE; SUBCHONDRAL BONE; OA; cartilage; synovitis; subchondral bone; inflammation; neuropeptides; macrophages; cytokines; topographical pattern; joint innervation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 11 Jan 2023 08:00 |
| Last Modified: | 11 Jan 2023 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46859 |
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