Evert, Katja and Kocher, T. and Schindler, A. and Müller, M. and Müller, K. and Pink, C. and Holtfreter, B. and Schmidt, A. and Dombrowski, F. and Schubert, A. and von Woedtke, T. and Rupf, S. and Calvisi, D. F. and Bekeschus, S. and Jablonowski, L. (2021) Repeated exposure of the oral mucosa over 12 months with cold plasma is not carcinogenic in mice. SCIENTIFIC REPORTS, 11 (1): 20672. ISSN 2045-2322
Full text not available from this repository. (Request a copy)Abstract
Peri-implantitis may result in the loss of dental implants. Cold atmospheric pressure plasma (CAP) was suggested to promote re-osseointegration, decrease antimicrobial burden, and support wound healing. However, the long-term risk assessment of CAP treatment in the oral cavity has not been addressed. Treatment with two different CAP devices was compared against UV radiation, carcinogen administration, and untreated conditions over 12 months. Histological analysis of 406 animals revealed that repeated CAP exposure did not foster non-invasive lesions or squamous cell carcinoma (SCCs). Carcinogen administration promoted non-invasive lesions and SCCs. Molecular analysis by a qPCR screening of 144 transcripts revealed distinct inflammatory profiles associated with each treatment regimen. Interestingly, CAP treatment of carcinogen-challenged mucosa did not promote but instead left unchanged or reduced the proportion of non-invasive lesions and SCC formation. In conclusion, repeated CAP exposure of murine oral mucosa was well tolerated, and carcinogenic effects did not occur, motivating CAP applications in patients for dental and implant treatments in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; ATMOSPHERIC PLASMA; OSTEOBLAST GROWTH; JET; EXPRESSION |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Aug 2022 04:41 |
| Last Modified: | 26 Aug 2022 04:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46933 |
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