Calvano Kuechler, Erika and Carelli, Julia and Morais, Nathaly D. and Brancher, Joao Armando and Condeixa de Franca Lopes, Celia Maria and Baratto-Filho, Flares and Paddenberg, Eva and Hueb de Menezes Oliveira, Maria Angelica and Moro, Alexandre and Kirschneck, Christian (2022) Assessing the association between vitamin D receptor and dental age variability. CLINICAL ORAL INVESTIGATIONS, 26 (2). pp. 1677-1682. ISSN 1432-6981, 1436-3771
Full text not available from this repository. (Request a copy)Abstract
Objectives To explore the association between genetic polymorphisms in vitamin D receptor (VDR), vitamin D serum levels, and variability in dental age. Material and methods This cross-sectional study was based on an oral examination, panoramic radiograph analysis, and genotype analysis from biological samples. Dental age was evaluated using two different methods: Demirjian et al. (Hum Biol 45:211-227, 1973) and Hofmann et al. (J Orofac Orthop.78:97-111, 2017). The genetic polymorphisms BglI (rs739837) and FokI (rs2228570) in VDR were genotyped through real-time PCR. The vitamin D level was also measured in the serum. Delta (dental age-chronological age) was compared among genotypes in VDR in the co-dominant model. Multiple linear regression analysis was also performed. An established alpha of 5% was used. Results Genotype distributions of BglI and FokI were not associated with dental maturity (p > 0.05). In the logistic regression analyses, genotypes in BglI and FokI and vitamin D levels were not associated with variability in dental age (p > 0.05). Conclusions The genetic polymorphisms BglI and FokI in VDR and the vitamin D levels were not associated with variability in dental age.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SKELETAL AGE; MOLAR; CALCIFICATION; POLYMORPHISM; DEFICIENCY; ACCURACY; GENE; Vitamin D; Genetic polymorphisms; VDR; Dental maturity; Dental development |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Sep 2022 11:19 |
| Last Modified: | 09 Sep 2022 11:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46942 |
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