Wolff, Daniel and Fatobene, Giancarlo and Rocha, Vanderson and Kroeger, Nicolaus and Flowers, Mary E. (2021) Steroid-refractory chronic graft-versus-host disease: treatment options and patient management. BONE MARROW TRANSPLANTATION, 56 (9). pp. 2079-2087. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Chronic graft-versus-host disease (cGVHD) is one of the major causes of late mortality after allogenic hematopoietic stem cell transplantation. Moderate-to-severe cGVHD is associated with poor health-related quality of life and substantial disease burden. While corticosteroids with or without calcineurin inhibitors comprise the first-line treatment option, the prognosis for patients with steroid-refractory cGVHD (SR-cGVHD) remains poor. The mechanisms underlying steroid resistance are unclear, and there are no standard second-line treatment guidelines for patients with SR-cGVHD. In this review, we provide an overview on current treatment options of cGVHD and use a series of theoretical case studies to elucidate the rationale of choices of second- and third-line treatment options for patients with SR-cGVHD based on individual patient profiles.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; BRONCHIOLITIS OBLITERANS SYNDROME; LOW-DOSE METHOTREXATE; TERM-FOLLOW-UP; BONE-MARROW; EXTRACORPOREAL PHOTOPHERESIS; CLINICAL-TRIALS; CHRONIC GVHD; PHASE-II |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 Dec 2022 07:45 |
| Last Modified: | 08 Dec 2022 07:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46985 |
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