Grafakou, Maria-Eleni and Barda, Christina and Pintac, Diandra and Lesjak, Marija and Heilmann, Joerg and Skaltsa, Helen (2021) Prenylated Acylphloroglucinols from Hypericum jovis with Anti-inflammatory Potential (#). PLANTA MEDICA, 87 (14). pp. 1184-1191. ISSN 0032-0943, 1439-0221
Full text not available from this repository. (Request a copy)Abstract
Thirteen prenylated acylphloroglucinols ( 1 - 13 ), including 2 previously undescribed compounds ( 1 ) and ( 2 ), were isolated from Hypericum jovis. Their structures were elucidated by high-field NMR spectroscopy. The isolated prenylated acylphloroglucinols were evaluated for their anti-inflammatory effects in vitro through the reduction of the intercellular adhesion molecule 1 expression induced by TNF- alpha in the human microvascular endothelial cells 1 cell line. Compounds 3, 5, 6, 8, and 12 significantly reduced intercellular adhesion molecule 1 expression in a concentration-dependent manner with IC (50) values of 16.9, 34.4, 4.0, 3.2, and 7.7 mu M, respectively. In addition, compound 12 showed notable inhibitory activity on the formation of cyclooxygenase-1- and 12-lipoxygenase-derived inflammatory mediators in an ex vivo cyclooxygenase-lipoxygenase assay. Eleven further constituents were isolated ( 14 - 24 ), including the rare quercetin 3-O-(2-O-acetyl)-arabinofuranoside ( 18 ).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHLOROGLUCINOL DERIVATIVES; ENDOTHELIAL-CELLS; HYPERFORIN; CONSTITUENTS; BARK; NMR; Hypericum jovis; Hypericaceae; prenylated acylphloroglucinols; inflammation; ICAM-1; COX-LOX |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2022 04:22 |
| Last Modified: | 12 Sep 2022 04:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47022 |
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