Electrochemical sensors targeting salivary biomarkers: A comprehensive review

Mani, Veerappan and Beduk, Tutku and Khushaim, Walaa and Ceylan, Ayse Elcin and Timur, Suna and Wolfbeis, Otto S. and Salama, Khaled Nabil (2021) Electrochemical sensors targeting salivary biomarkers: A comprehensive review. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 135: 116164. ISSN 0165-9936, 1879-3142

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Abstract

The analysis of salivary markers has grown into a promising non-invasive route for easy, safe, and pain-free monitoring and has the potential to alter the existing way of clinical diagnosis and management. Advancements in sensing technology, the arrival of novel materials, the innovative fabrication technologies, and sampling accuracy have made significant progress and establishing saliva as a fluid for routine analysis. Salivary biomarkers are useful to diagnose not only cardiovascular diseases, bacterial or viral infections but also cancer, diabetes, or Alzheimer's disease. In addition, saliva is analyzed in toxicology, forensic medicine and drug abuse. Electrochemical assays and sensors are well accepted tools because they allow for fast and cost-effective analysis. Nanomaterials, microfluidics, smartphones, paper-based, flexible and wearable devices have made significant advancements in saliva analysis. This review discusses the recent progress made in electrochemical methodologies for detecting salivary biomarkers. (C) 2020 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Clinical diagnostics; Saliva; Biomarker; Biosensor; Viral disease; Cardiovascular disease; Cancer; Drug abuse; Wearable sensors; Microfluidics
Subjects: 500 Science > 540 Chemistry & allied sciences
Divisions: Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik
Depositing User: Petra Gürster
Date Deposited: 17 Jan 2023 06:20
Last Modified: 17 Jan 2023 06:20
URI: https://pred.uni-regensburg.de/id/eprint/47060

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