Zhou, Yi and Tao, Junyan and Calvisi, Diego F. and Chen, Xin (2022) Role of Lipogenesis Rewiring in Hepatocellular Carcinoma. SEMINARS IN LIVER DISEASE, 42 (01). pp. 77-86. ISSN 0272-8087, 1098-8971
Full text not available from this repository. (Request a copy)Abstract
Metabolic rewiring is one of the hallmarks of cancer. Altered de novo lipogenesis is one of the pivotal metabolic events deregulated in cancers. Sterol regulatory element-binding transcription factor 1 (SREBP1) controls the transcription of major enzymes involved in de novo lipogenesis, including ACLY, ACACA, FASN, and SCD. Studies have shown the increased de novo lipogenesis in human hepatocellular carcinoma (HCC) samples. Multiple mechanisms, such as activation of the AKT/mechanistic target of rapamycin (mTOR) pathway, lead to high SREBP1 induction and the coordinated enhanced expression of ACLY , ACACA , FASN, and SCD genes. Subsequent functional analyses have unraveled these enzymes' critical role(s) and the related de novo lipogenesis in hepatocarcinogenesis. Importantly, targeting these molecules might be a promising strategy for HCC treatment. This paper comprehensively summarizes de novo lipogenesis rewiring in HCC and how this pathway might be therapeutically targeted.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FATTY-ACID SYNTHASE; ATP-CITRATE LYASE; BINDING PROTEIN CHREBP; DE-NOVO LIPOGENESIS; LIPID-METABOLISM; MOLECULAR CLASSIFICATION; CELL-PROLIFERATION; ACETYL-COENZYME; KEY PLAYER; CANCER; hepatocellular carcinoma; lipogenesis; targeted therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Nov 2022 06:24 |
| Last Modified: | 29 Nov 2022 06:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47090 |
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