Pabel, Steffen and Hamdani, Nazha and Singh, Jagdeep and Sossalla, Samuel (2021) Potential Mechanisms of SGLT2 Inhibitors for the Treatment of Heart Failure With Preserved Ejection Fraction. FRONTIERS IN PHYSIOLOGY, 12: 752370. ISSN 1664-042X
Full text not available from this repository. (Request a copy)Abstract
Heart failure with preserved ejection fraction (HFpEF) is an unsolved and growing concern in cardiovascular medicine. While no treatment options that improve prognosis in HFpEF patients has been established so far, SGLT2 inhibitors (SGLT2i) are currently being investigated for the treatment of HFpEF patients. SGLT2i have already been shown to mitigate comorbidities associated with HFpEF such as type 2 diabetes and chronic renal disease, however, more recently there has been evidence that they may also directly improve diastolic function. In this article, we discuss some potential beneficial mechanisms of SGLT2i in the pathophysiology of HFpEF with focus on contractile function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LATE SODIUM CURRENT; DIASTOLIC DYSFUNCTION; OXIDATIVE STRESS; NA+/H+ EXCHANGER; BLOOD-PRESSURE; KINASE-II; EMPAGLIFLOZIN; TITIN; INFLAMMATION; CALCIUM; heart failure; HFpEF-heart failure with preserved ejection fraction; SGLT2 inhibitors; diastolic function; inflammation; oxidative stress |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Petra Gürster |
| Date Deposited: | 17 Jan 2023 06:56 |
| Last Modified: | 17 Jan 2023 06:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47096 |
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