Sedlmeier, Anja M. and Baumeister, Sebastian E. and Weber, Andrea and Fischer, Beate and Thorand, Barbara and Ittermann, Till and Doerr, Marcus and Felix, Stephan B. and Voelzke, Henry and Peters, Annette and Leitzmann, Michael F. (2021) Relation of body fat mass and fat-free mass to total mortality: results from 7 prospective cohort studies. AMERICAN JOURNAL OF CLINICAL NUTRITION, 113 (3). pp. 639-646. ISSN 0002-9165, 1938-3207
Full text not available from this repository. (Request a copy)Abstract
Background: Fat mass and fat-free mass may play independent roles in mortality risk but available studies on body composition have yielded inconsistent results. Objective: The aim was to determine the relations of body fat mass and fat-free mass to risk of mortality. Methods: In pooled data from 7 prospective cohorts encompassing 16,155 individuals aged 20 to 93 y (median, 44 y), we used Cox regression and restricted cubic splines to estimate HRs and 95% CIs for the relation of body composition, measured by bioelectrical impedance analysis, to total mortality. We adjusted for age, study, sex, ethnicity. history of diabetes mellitus, education, smoking. physical activity, and alcohol consumption. Results: During a median follow-up period of 14 y (range, 3-21 y), 1347 deaths were identified. After mutual adjustment for fat mass and fat-free mass, fat mass showed a J-shaped association with mortality (overall P value < 0.001; P for nonlinearity = 0.003). Using a fat mass index of 7.3 kg/m(2) as the reference, a high fat mass index of 13.0 kg/m(2) was associated with an HR of 1.56 (95% CI: 1.30, 1.87). In contrast, fat-free mass showed an inverse association with mortality (overall P value < 0.001; P for nonlinearity = 0.001). Compared with a low fat-free mass index of 16.1 kg/m(2), a high fat-free mass of 21.9 kg/m(2) was associated with an HR of 0.70 (95% CI: 036, 0.87). Conclusions: Fat mass and fat-free mass show opposing associations with mortality. Excess fat mass is related to increased mortality risk, whereas fat-free mass protects against risk of mortality. These findings suggest that body composition provides important prognostic information on an individual's mortality risk not provided by traditional proxies of adiposity such as BMI.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ALL-CAUSE MORTALITY; 2ND NATIONAL-HEALTH; FOLLOW-UP; SKELETAL-MUSCLE; OBESITY; INDEX; OLDER; ADIPOSITY; MEN; ASSOCIATIONS; obesity; body composition; fat mass; fat-free mass; mortality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2022 10:59 |
| Last Modified: | 12 Sep 2022 10:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47126 |
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