Maiti, Binoy and Ng, Gervase and Abramov, Alex and Boyer, Cyrille and Diaz, David Diaz (2021) Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation. POLYMER CHEMISTRY, 12 (27). pp. 3968-3975. ISSN 1759-9954, 1759-9962
Full text not available from this repository.Abstract
Carbon monoxide (CO) is being increasingly appreciated as a major physiological gasomediator and plays significant roles in different biological activities. However, site-specific delivery of this toxic gas faces major difficulties in the healthcare system in terms of unavailability of appropriate equipment for delivery. A well-known and most studied carbon monoxide releasing molecule (CORM) is tricarbonyldichlororuthenium(ii) dimer (Ru2Cl4(CO)(6)). However, its use as a therapeutic agent is restricted due to its poor water solubility and a short half-life. In order to solve this issues we have designed and synthesized a water-soluble methionine (methionine methacryloyloxyethyl ester (METMA)) and poly(ethylene glycol methyl ether methacrylate) containing block-copolymer via reversible addition-fragmentation chain transfer (RAFT) polymerization and attached the CORM in the methionine side chain units. Inductively coupled plasma optical emission spectrometry (ICP-OES) and FT-IR confirms the presence of CORM molecule into the polymer. The time-dependent CO release from CORM conjugated block-copolymer was investigated by a myoglobin assay. This CORM conjugated block-copolymer slowly and spontaneously released CO with sustained-release kinetics. Moreover, this CO-releasing polymer was able to prevent biofilm formation against Pseudomonas aeruginosa.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NO-DONOR PRODRUGS; PSEUDOMONAS-AERUGINOSA; DELIVERY; MOLECULES; LIGHT; PHOTOCORMS; COMPLEXES; SCAFFOLDS; RAFT |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Sep 2022 05:52 |
| Last Modified: | 01 Sep 2022 05:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47131 |
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