Dahlmann, Anke and Linz, Peter and Zucker, Isabelle and Haag, Viktor and Jantsch, Jonathan and Dienemann, Thomas and Nagel, Armin M. and Neubert, Patrick and Rosenhauer, Daniela and Rauh, Manfred and Horn, Stephan and Mueller, Dominik N. and Schiffer, Mario and Luft, Friedrich C. and Uder, Michael and Kopp, Christoph (2021) Reduction of Tissue Na+ Accumulation After Renal Transplantation. KIDNEY INTERNATIONAL REPORTS, 6 (9). pp. 2338-2347. ISSN 2468-0249,
Full text not available from this repository. (Request a copy)Abstract
Introduction: Chronic kidney disease (CKD) engenders salt-sensitive hypertension. Whether or not tissue Nathorn accumulation is increased in CKD patients remains uncertain. How tissue Nathorn is affected after renal transplantation has not been assessed. Methods: We measured tissue Na+ amount in 31 CKD patients (stage 5) and prospectively evaluated tissue Na+ content at 3 and 6 months, following living-donor kidney transplantation. Additionally, pre- and post-transplantation data were compared to 31 age- and sex-matched control subjects. Na-23-magnetic resonance imaging (Na-23-MRI) was used to quantify muscle and skin Na+ of the lower leg and water distribution was assessed by bioimpedance spectroscopy. Results: Compared to control subjects, CKD patients showed increased muscle (20.7 +/- 5.0 vs. 15.5 +/- 1.8 arbitrary units [a.u.], P < 0.001) and skin Na+ content (21.4 +/- 7.7 vs. 15.0 +/- 2.3 a.u., P < 0.001), whereas plasma Na+ concentration did not differ between groups. Restoration of kidney function by successful renal transplantation was accompanied by mobilization of tissue Na+ from muscle (20.7 +/- 5.0 vs. 16.8 +/- 2.8 a.u., P < 0.001) and skin tissue (21.4 +/- 7.7 vs. 16.8 +/- 5.2 a.u., P < 0.001). The reduction of tissue Na+ after transplantation was associated with improved renal function, normalization of blood pressure as well as an increase in lymphatic growth-factor concentration (vascular endothelial growth factor C [VEGF-C] 4.5 +/- 1.8 vs. 6.7 +/- 2.7 ng/ml, P < 0.01). Conclusions: Tissue Na+ accumulation in predialysis patients with CKD was almost completely reversed to the level of healthy controls after successful kidney transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-C; CHRONIC KIDNEY-DISEASE; SODIUM; MORTALITY; HYPERTENSION; EXPRESSION; HYDRATION; OVERLOAD; VOLUME; FLUID; chronic kidney disease; kidney transplantation; tissue Na+; Na-23-magnetic resonance imaging; vascular endothelial growth factor C |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2022 07:04 |
| Last Modified: | 12 Sep 2022 07:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47137 |
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