Dugas, Martin and Grote-Westrick, Tanja and Merle, Uta and Fontenay, Michaela and Kremer, Andreas E. and Hanses, Frank and Vollenberg, Richard and Lorentzen, Eva and Tiwari-Heckler, Shilpa and Duchemin, Jerome and Ellouze, Syrine and Vetter, Marcel and Fuerst, Julia and Schuster, Philipp and Brix, Tobias and Denkinger, Claudia M. and Mueller-Tidow, Carsten and Schmidt, Hartmut and Tepasse, Phil-Robin and Kuehn, Joachim (2021) Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19. JOURNAL OF CLINICAL VIROLOGY, 139: 104847. ISSN 1386-6532, 1873-5967
Full text not available from this repository. (Request a copy)Abstract
Background: The vast majority of COVID-19 patients experience a mild disease. However, a minority suffers from critical disease with substantial morbidity and mortality. Objectives: To identify individuals at risk of critical COVID-19, the relevance of a seroreactivity against seasonal human coronaviruses was analyzed. Methods: We conducted a multi-center non-interventional study comprising 296 patients with confirmed SARS-CoV-2 infections from four tertiary care referral centers in Germany and France. The ICU group comprised more males, whereas the outpatient group contained a higher percentage of females. For each patient, the serum or plasma sample obtained closest after symptom onset was examined by immunoblot regarding IgG antibodies against the nucleocapsid protein (NP) of HCoV 229E, NL63, OC43 and HKU1. Results: Median age was 60 years (range 18-96). Patients with critical disease (n=106) had significantly lower levels of anti-HCoV OC43 nucleocapsid protein (NP)-specific antibodies compared to other COVID-19 inpatients (p=0.007). In multivariate analysis (adjusted for age, sex and BMI), OC43 negative inpatients had an increased risk of critical disease (adjusted odds ratio (AOR) 2.68 [95% CI 1.09 -7.05]), higher than the risk by increased age or BMI, and lower than the risk by male sex. A risk stratification based on sex and OC43 serostatus was derived from this analysis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; OC43; Seasonal coronavirus; COVID-19; SARS-CoV-2; Critical disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Abteilung für Krankenhaushygiene und Infektiologie Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2022 11:10 |
| Last Modified: | 12 Sep 2022 11:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47178 |
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