Schoch, Stephanie and Walti, Martin and Schemmerer, Mathias and Alexander, Rick and Keiner, Bjoern and Kralicek, Carol and Bycholski, Keith and Hyatt, Kelley and Knowles, Jon and Klochkov, Denis and Simon, Toby and Wenzel, Juergen J. and Roth, Nathan J. and Widmer, Eleonora (2021) Hepatitis A Virus Incidence Rates and Biomarker Dynamics for Plasma Donors, United States. EMERGING INFECTIOUS DISEASES, 27 (11). pp. 2817-2824. ISSN 1080-6040, 1080-6059
Full text not available from this repository. (Request a copy)Abstract
The United States is currently affected by widespread hepatitis A virus (HAV) outbreaks. We investigated HAV incidence rates among source plasma donors in the United States since 2016. Serial donations from HAV-positive frequent donors were analyzed for common biologic markers to obtain a detailed picture of the course of infection. We found a considerable increase in incidence rates with shifting outbreak hotspots over time. Although individual biomarker profiles were highly variable, HAV RNA typically had a high peak and a biphasic decrease and often remained detectable for several months. One donor had a biomarker pattern indicative of previous exposure. Our findings show that current HAV outbreaks have been spilling over into the plasma donor population. The detailed results presented improve our comprehension of HAV infection and related public health aspects. In addition, the capture of full RNA curves enables estimation of HAV doubling time.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFECTION; VACCINATION; VIREMIA; HBV; HCV; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2022 11:54 |
| Last Modified: | 12 Sep 2022 11:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47212 |
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