Disse, Sigrid C. and Manuylova, Tatiana and Adam, Klaus and Lechler, Annette and Zant, Robert and Klingel, Karin and Aepinus, Christian and Finkenzeller, Thomas and Wellmann, Sven and Schneble, Fritz (2021) COVID-19 in 28-Week Triplets Caused by Intrauterine Transmission of SARS-CoV-2-Case Report. FRONTIERS IN PEDIATRICS, 9: 812057. ISSN 2296-2360,
Full text not available from this repository. (Request a copy)Abstract
Since the beginning of the COVID-19 pandemic, in-utero transmission of SARS-CoV-2 remains a rarity and only very few cases have been proven across the world. Here we depict the clinical, laboratory and radiologic findings of preterm triplets born at 28 6/7 weeks to a mother who contracted COVID-19 just 1 week before delivery. The triplets showed SARS-CoV-2 positivity right after birth, developed significant leukopenia and early-onset pulmonary interstitial emphysema. The most severely affected triplet I required 10 days of high-frequency oscillatory ventilation due to failure of conventional invasive ventilation, and circulatory support for 4 days. Despite a severe clinical course in two triplets (triplet I and II), clinical management without experimental, targeted antiviral drugs was successful. At discharge home, the triplets showed no signs of neurologic or pulmonary sequelae. Placental immunohistology with SARS-CoV-2 N-protein localized strongly to syncytiotrophoblast cells and, to a lesser extent, to fetal Hofbauer cells, proving intrauterine virus transmission. We discuss the role of maternal viremia as a potential risk factor for vertical transmission. To the best of our knowledge, our report presents the earliest unequivocally confirmed prenatal virus transmission in long-term surviving children, i.e., at the beginning of the third trimester.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERTICAL TRANSMISSION; PREGNANCY; INFECTION; OUTCOMES; COHORT; vertical transmission; case report; triplets; neonate; SARS-CoV-2; preterm; COVID-19 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2022 05:42 |
| Last Modified: | 13 Sep 2022 05:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47240 |
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