Salehi, Mohammad Saied and Safari, Anahid and Pandamooz, Sareh and Jurek, Benjamin and Hooshmandi, Etrat and Owjfard, Maryam and Bayat, Mahnaz and Zafarmand, Seyedeh Shaghayegh and Miyan, Jaleel A. and Borhani-Haghighi, Afshin (2022) The Beneficial Potential of Genetically Modified Stem Cells in the Treatment of Stroke: a Review. STEM CELL REVIEWS AND REPORTS, 18 (2). pp. 412-440. ISSN 2629-3269, 2629-3277
Full text not available from this repository. (Request a copy)Abstract
The last two decades have witnessed a surge in investigations proposing stem cells as a promising strategy to treat stroke. Since growth factor release is considered as one of the most important aspects of cell-based therapy, stem cells over-expressing growth factors are hypothesized to yield higher levels of therapeutic efficiency. In pre-clinical studies of the last 15 years that were investigating the efficiency of stem cell therapy for stroke, a variety of stem cell types were genetically modified to over-express various factors. In this review we summarize the current knowledge on the therapeutic efficiency of stem cell-derived growth factors, encompassing techniques employed and time points to evaluate. In addition, we discuss several types of stem cells, including the recently developed model of epidermal neural crest stem cells, and genetically modified stem cells over-expressing specific factors, which could elevate the restorative potential of naive stem cells. The restorative potential is based on enhanced survival/differentiation potential of transplanted cells, apoptosis inhibition, infarct volume reduction, neovascularization or functional improvement. Since the majority of studies have focused on the short-term curative effects of genetically engineered stem cells, we emphasize the need to address their long-term impact.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOCAL CEREBRAL-ISCHEMIA; MARROW STROMAL CELLS; PROMOTES FUNCTIONAL RECOVERY; FIBROBLAST-GROWTH-FACTOR; NEUROTROPHIC FACTOR; ARTERY OCCLUSION; PROVIDE NEUROPROTECTION; THERAPEUTIC BENEFITS; SCIATIC-NERVE; INFARCT SIZE; Cell therapy; MCAO; Stroke; Genetic engineering; Growth factors; Stem cells |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Nov 2022 06:35 |
| Last Modified: | 29 Nov 2022 06:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47319 |
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