Berchtold, Valeria and Messner, Franka and Weissenbacher, Annemarie and Oberhuber, Rupert and Entenmann, Andreas and Aldrian, Denise and Vogel, Georg and Margreiter, Christian and Ulmer, Hanno and Krapf, Johanna and Cardini, Benno and Schlitt, Hans J. and Margreiter, Raimund and Ofner, Dietmar and Mueller, Thomas and Schneeberger, Stefan (2021) Influence of early biliary complications on survival rates after pediatric liver transplantation-A positive outlook. PEDIATRIC TRANSPLANTATION, 25 (7): e14075. ISSN 1397-3142, 1399-3046
Full text not available from this repository. (Request a copy)Abstract
Background Early biliary complications (EBC) constitute a burden after pediatric liver transplantation frequently requiring immediate therapy. We aimed to assess the impact of EBC on short- and long-term patient and graft survival as well as post-transplant morbidity. Methods We analyzed 121 pediatric liver transplantations performed between 1984 and 2019 at the Medical University of Innsbruck for the occurrence of early (<90 days) biliary complications and investigated the influence of EBC on patient and graft survival. Results Early biliary complications occurred in 30 (24.8%) out of the 121 pediatric liver transplant recipients. Patient survival at 15 years (89.2% vs. 84.2%, p = .65) and all-cause (82.5% vs. 74.0%) and death-censored graft survival (82.5% vs. 75.1%, p = .71) at 10 years were similar between the EBC and the non-EBC group. The EBC group had a significantly longer ICU (25 vs. 16 days, p < .001) and initial hospital stay (64 vs. 42 days, p = .002). Livers of patients with EBC were characterized by multiple bile ducts (33.3% vs. 13.2%, p = .027), and patients with EBC had a higher risk to develop late biliary complications (OR 2.821 [95% CI 1.049-7.587], p = .044) and bowel obstruction/perforation (OR 4.388 [95% CI 1.503-12.812], p = .007). Conclusion Early biliary complications after pediatric liver transplantation is frequent. The occurrence of EBC significantly increased post-transplant morbidity without affecting mortality. Multiple bile ducts were the only risk factor for the development of EBC in our cohort.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BILE-DUCTS; RISK-FACTORS; DONOR; MANAGEMENT; RECONSTRUCTION; RECIPIENTS; LEAKAGE; STRICTURES; EXPERIENCE; DIAGNOSIS; early biliary complications; pediatric liver transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2022 13:51 |
| Last Modified: | 13 Sep 2022 13:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47364 |
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