Stokkel, Laura E. and van Montfoort, Maurits L. and van Boven, Hester H. and Mertens, Laura S. and van Rhijn, Bas W. G. (2021) Two Patients with Urachal Cancer with Multifocal Adenocarcinoma Recurrences in the Urothelium of the Prostatic and Penile Urethra. EUROPEAN UROLOGY OPEN SCIENCE, 33. pp. 56-60. ISSN 2666-1691, 2666-1683
Full text not available from this repository. (Request a copy)Abstract
We report two cases with recurrences of urachal adenocarcinoma (UrAC) in the urethra. Both patients had mucinous UrAC without metastasis, for which they were treated with en-bloc partial cystectomy and umbilectomy. The first patient developed recurrence of UrAC in the distal urethra after 1 yr. Distal urethrectomy revealed multiple additional recurrences in the penile and prostatic urethra. The patient underwent radical cystoprostatectomy with en-bloc urethrectomy. At 5 mo after surgery, liver metastases were found. A search in our institutional database revealed a second patient who developed a solitary recurrence of UrAC in the prostatic urethra 8 yr after partial cystectomy. Radical cystoprostatectomy was performed. The patient subsequently experienced recurring UrAC in the urethra, which were treated with multiple surgeries and radiation. Unfortunately, local tumor control could not be achieved and the patient developed distant metastases 7 yr after cystoprostatectomy. Our two cases and four comparable cases reported in the literature indicate that urothelial spread of UrAC is rare but possible. It remains to be determined if UrAC spreads along the urothelium similar to urothelial cancer or if these multifocal urethral recurrences were the first sign of local metastasis. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of European Association of Urology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARCINOMA; OUTCOMES; Urachal cancer; Recurrence; Urethra; Urothelial; Adenocarcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2022 14:37 |
| Last Modified: | 13 Sep 2022 14:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47367 |
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