Muehl-Benninghaus, Ruben and Fries, Frederik and Kiessling, Mara and Tomori, Toshiki and Krajewski, Stefanie and Simgen, Andreas and Bauer, Sabina and Hey, Natascha and Brynda, Eduard and Taborska, Johanka and Riedel, Tomas and Reith, Wolfgang and Cattaneo, Giorgio and Brochhausen, Christoph (2022) Vascular Response on a Novel Fibrin-Based Coated Flow Diverter. CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 45 (2). pp. 236-243. ISSN 0174-1551, 1432-086X
Full text not available from this repository. (Request a copy)Abstract
Purpose Due to thromboembolic complications and in-stent-stenosis after flow diverter (FD) treatment, the long-term use of dual antiplatelet treatment (DAPT) is mandatory. The tested nano-coating has been shown to reduce material thrombogenicity and promote endothelial cell proliferation in vitro. We compared the biocompatibility of coated (Derivo Heal) and non-coated (Derivo bare) FDs with DAPT in an animal model. Methods Derivo (R) bare (n = 10) and Derivo (R) Heal (n = 10) FD were implanted in the common carotid arteries (CCAs) of New Zealand white rabbits. One additional FD, alternately a Derivo bare (n = 5) or Derivo Heal (n = 5), was implanted in the abdominal aorta (AA) for assessment of the patency of branch arteries. Histopathological examinations were performed after 28 days. Angiography was performed before and after FD implantation and at follow-up. Results Statistical analysis of the included specimens showed complete endothelialization of all FDs with no significant differences in neointima thickness between Derivo (R) bare and Derivo (R) Heal (CCA: p = 0.91; AA: p = 0.59). A significantly reduced number of macrophages in the vessel wall of the Derivo Heal was observed for the CCA (p = 0.02), and significantly reduced fibrin and platelet deposition on the surface of the Derivo Heal was observed for the AA. All branch arteries of the stented aorta remained patent. Conclusion In this animal model, the novel fibrin-based coated FD showed a similar blood and tissue compatibility as the non-coated FD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STENT-ASSISTED COILING; INTRACRANIAL ANEURYSMS; DIFFERENTIATION; THROMBOGENICITY; DIVERSION; Flow diverter; Coating; Surface modification; Biocompatibility |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2022 15:00 |
| Last Modified: | 13 Sep 2022 15:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47395 |
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