Graf, Marion and Boettcher, Hans-Christian and Metzler-Nolte, Nils and Suenkel, Karlheinz and Thavalingam, Sugina and Czerwieniec, Rafal (2021) Cytotoxic Activities of Bis-cyclometalated Rhodium(III) and Iridium(III) Complexes Containing 2,2 '-Biphenyldiamine. ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 647 (5). pp. 519-524. ISSN 0044-2313, 1521-3749
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The synthesis and characterization of new bis-cyclometalated complex salts [M(ptpy)(2)(2,2'-biphenyldiamine)]PF6 (M=Rh, 1; M=Ir, 2; ptpy=2-(p-tolyl)pyridinato) are described. Compounds 1 and 2 were obtained by bridge-splitting reactions of [{M(mu-Cl)(ptpy)(2)}(2)] (M=Rh or Ir) with 2,2'-biphenyldiamine in CH2Cl2/MeOH/H2O mixtures. The molecular structure of compound 2 in the crystal was confirmed by single-crystal X-ray diffraction. 2 crystallized from dichloromethane/methanol/n-heptane in the monoclinic space group P2(1)/(n). The cytotoxic activities of both new compounds were examined and evaluated. Compound 1 and 2 exhibit significant cytotoxicity against human cancer cell lines with the IC50 values in the low micromolar range.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; 2,2 '-Biphenyldiamine; Cyclometalated complexes; Cytotoxic activity; Iridium; Rhodium |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 08:36 |
| Last Modified: | 14 Sep 2022 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47409 |
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