Baumeister, Sebastian-Edgar and Nolde, Michael and Alayash, Zoheir and Leitzmann, Michael and Baurecht, Hansjorg and Meisinger, Christa (2021) Cannabis use does not impact on type 2 diabetes: A two-sample Mendelian randomization study. ADDICTION BIOLOGY, 26 (6): e13020. ISSN 1355-6215, 1369-1600
Full text not available from this repository. (Request a copy)Abstract
Cannabis has effects on the insulin/glucose metabolism. As the use of cannabis and the prevalence of type 2 diabetes increase worldwide, it is important to examine the effect of cannabis on the risk of diabetes. We conducted a Mendelian randomization (MR) study by using 19 single-nucleotide polymorphisms (SNPs) as instrumental variables for lifetime cannabis use and 14 SNPs to instrument cannabis use disorder and linking these to type 2 diabetes risk using genome-wide association study data (lifetime cannabis use [N = 184,765]; cannabis use disorder [2387 cases/48,985 controls], type 2 diabetes [74,124 cases/824,006 controls]). The MR analysis suggested no effect of lifetime cannabis use (inverse-variance weighted odds ratio [95% confidence interval] = 1.00 [0.93-1.09], P value = 0.935) and cannabis use disorder (OR = 1.03 [0.99-1.08]) on type 2 diabetes. Sensitivity analysis to assess potential pleiotropy led to no substantive change in the estimates. This study adds to the evidence base that cannabis use does not play a causal role in type 2 diabetes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOVASCULAR RISK-FACTORS; MARIJUANA USE; MELLITUS; HEALTH; cannabis; diabetes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 08:38 |
| Last Modified: | 14 Sep 2022 08:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47410 |
Actions (login required)
 |
View Item |
