Abdel-Aziz, Mahmoud I. and Neerincx, Anne H. and Vijverberg, Susanne J. H. and Hashimoto, Simone and Brinkman, Paul and Gorenjak, Mario and Toncheva, Antoaneta A. and Harner, Susanne and Brandstetter, Susanne and Wolff, Christine and Perez-Garcia, Javier and Hedman, Anna M. and Almqvist, Catarina and Corcuera-Elosegui, Paula and Korta-Murua, Javier and Sardon-Prado, Olaia and Pino-Yanes, Maria and Potocnik, Uros and Kabesch, Michael and Kraneveld, Aletta D. and van der Zee, Anke H. (2021) A System Pharmacology Multi-Omics Approach toward Uncontrolled Pediatric Asthma. JOURNAL OF PERSONALIZED MEDICINE, 11 (6): 484. ISSN , 2075-4426
Full text not available from this repository. (Request a copy)Abstract
There is a clinical need to identify children with poor asthma control as early as possible, to optimize treatment and/or to find therapeutic alternatives. Here, we present the "Systems Pharmacology Approach to Uncontrolled Pediatric Asthma" (SysPharmPediA) study, which aims to establish a pediatric cohort of moderate-to-severe uncontrolled and controlled patients with asthma, to investigate pathophysiological mechanisms underlying uncontrolled moderate-to-severe asthma in children on maintenance treatment, using a multi-omics systems medicine approach. In this multicenter observational case-control study, moderate-to-severe asthmatic children (age; 6-17 years) were included from four European countries (Netherlands, Germany, Spain, and Slovenia). Subjects were classified based on asthma control and number of exacerbations. Demographics, current and past patient/family history, and clinical characteristics were collected. In addition, systems-wide omics layers, including epi(genomics), transcriptomics, microbiome, proteomics, and metabolomics were evaluated from multiple samples. In all, 145 children were included in this cohort, 91 with uncontrolled (median age = 12 years, 43% females) and 54 with controlled asthma (median age = 11.7 years, 37% females). The two groups did not show statistically significant differences in age, sex, and body mass index z-score distribution. Comprehensive information and diverse noninvasive biosampling procedures for various omics analyses will provide the opportunity to delineate underlying pathophysiological mechanisms of moderate-to-severe uncontrolled pediatric asthma. This eventually might reveal novel biomarkers, which could potentially be used for noninvasive personalized diagnostics and/or treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHILDHOOD; BURDEN; CHILDREN; pediatric asthma; uncontrolled asthma; omics; systems medicine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 07:36 |
| Last Modified: | 14 Sep 2022 07:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47418 |
Actions (login required)
 |
View Item |
