Joehrens, Korinna and Dietmaier, Wolfgang and Utpatel, Kirsten and Dietel, Manfred and Rueschoff, Josef and Fischer, Josephine (2021) Quality assurance in dMMR and MSI diagnostics. PATHOLOGE, 42 (4). pp. 405-413. ISSN 0172-8113, 1432-1963
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Deficient mismatch repair (dMMR) and microsatellite instability (MSI) have therapeutic relevance not only for colorectal carcinomas but also for carcinomas of other entities (endometrium, biliary tract, pancreas). In order to guarantee the knowledge and good technical quality necessary for adequate implementation of the corresponding analyses in pathology institutes, the Pathology Quality Assurance Initiative ("Die Qualitatssicherung-Initiative Pathologie") has been offering proficiency tests (PT) for years. It has been shown for the dMMR PT that various antibody clones from different manufacturers provide comparable results in immunohistological examinations, except for slight variations. The difficulty lies in the staining protocol (intensity of staining) and the interpretation of the staining results. The molecular pathological MSI PT has shown a positive trend at a high-quality level over the last three years. Success rates increased from 89 (2018) to 97% (2019/2020). The choice of assay, whether commercial or in-house tests with the designated cutoffs for this purpose, has not been shown to have a significant impact on the PTs in the selected EQA samples.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Colorectal neoplasms; DNA mismatch repair; Microsatellite instability; Molecular pathology; Quality control |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 08:43 |
| Last Modified: | 14 Sep 2022 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47427 |
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