Ignatov, Tanja and Gassner, Johannes and Bozukova, Mihaela and Ivros, Stylianos and Meszaros, Jozsef and Ortmann, Olaf and Eggemann, Holm and Ignatov, Atanas (2021) Contralateral lymph node metastases in patients with vulvar cancer and unilateral sentinel lymph node metastases. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 100 (8). pp. 1520-1525. ISSN 0001-6349, 1600-0412
Full text not available from this repository. (Request a copy)Abstract
Introduction The risk of contralateral lymph node metastases following unilateral sentinel lymph node (SLN) metastases in patients with vulvar cancer(s) remains to be systematically assessed. Material and methods We performed a multicenter, retrospective registry-based study of 476 patients with vulvar cancer. The primary outcome measure was the rate of contralateral non-SLN metastases in the case of positive unilateral SLN. Results Out of 476 patients with primary vulvar cancer, 202 received SLN biopsy: 58 unilateral and 144 bilateral. Out of 66 patients with unilateral metastatic SLN, 62 (93.9%) received contralateral lymphadenectomy-18 after unilateral and 44 after bilateral SLN biopsy. In the study group, 132 SLN were assessed with a median number of 2 (range 1-4) per patient and 76 of these were positive. Lymph node-positivity was associated with advanced tumor stage, as well as lymph and vascular space invasion. In the group of patients with bilateral inguino-femoral lymphadenectomy, 1004 lymph nodes were resected with a median number of 15 (range 10-29) per patient. After full dissection of the inguino-femoral lymph nodes, no contralateral non-SLN metastases were found. Conclusions The risk of contralateral non-SLN metastases in patients with unilateral SLN metastases was low. Therefore, the impact of contralateral lymphadenectomy on patient survival should be investigated in further studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; cancer; lymphadenectomy; metastases; sentinel node; vulvar; vulvar cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 08:51 |
| Last Modified: | 14 Sep 2022 08:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47431 |
Actions (login required)
 |
View Item |
