Lopez-Almela, Inmaculada and Romani-Perez, Marina and Bullich-Vilarrubias, Clara and Benitez-Paez, Alfonso and Gomez Del Pulgar, Eva M. and Frances, Ruben and Liebisch, Gerhard and Sanz, Yolanda (2021) Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice. GUT MICROBES, 13 (1). pp. 1-20. ISSN 1949-0976, 1949-0984
Full text not available from this repository. (Request a copy)Abstract
Gut microbiota represents a therapeutic target for obesity. We hypothesize that B. uniformis CECT 7771 combined with wheat bran extract (WBE), its preferred carbon source, may exert superior anti-obesity effects. We performed a 17-week intervention in diet-induced obese mice receiving either B. uniformis, WBE, or their combination to identify interactions and independent actions on metabolism and immunity. B. uniformis combined with WBE was the most effective intervention, curbing weight gain and adiposity, while exerting more modest effects separately. The combination restored insulin-dependent metabolic routes in fat and liver, although the bacterium was the primary driver for improving whole-body glucose disposal. Moreover, B. uniformis-combined with WBE caused the highest increases in butyrate and restored the proportion of induced intraepithelial lymphocytes and type-3 innate lymphoid cells in the intestinal epithelium. Thus, strengthening the first line of immune defense against unhealthy diets and associated dysbiosis in the intestine. This intervention also attenuated the altered IL22 signaling and liver inflammation. Our study shows opportunities for employing B. uniformis, combined with WBE, to aid in the treatment of obesity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GUT MICROBIOTA; FATTY-ACIDS; GLUCOSE; HOMEOSTASIS; INTERLEUKIN-22; INFLAMMATION; LIPOGENESIS; Obesity; dietary fiber; microbiota; intraepithelial lymphocytes; innate lymphoid cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 09:00 |
| Last Modified: | 14 Sep 2022 09:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47434 |
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