Rao, Disha and Verburg, Fabienne and Renner, Kathrin and Peeper, Daniel S. and Lacroix, Ruben and Blank, Christian U. (2021) Metabolic profiles of regulatory T cells in the tumour microenvironment. CANCER IMMUNOLOGY IMMUNOTHERAPY, 70 (9). pp. 2417-2427. ISSN 0340-7004, 1432-0851
Full text not available from this repository. (Request a copy)Abstract
Metabolic reprogramming of cancer cells generates a tumour microenvironment (TME) characterised by nutrient restriction, hypoxia, acidity and oxidative stress. While these conditions are unfavourable for infiltrating effector T cells, accumulating evidence suggests that regulatory T cells (Tregs) continue to exert their immune-suppressive functions within the TME. The advantages of Tregs within the TME stem from their metabolic profile. Tregs rely on oxidative phosphorylation for their functions, which can be fuelled by a variety of substrates. Even though Tregs are an attractive target to augment anti-tumour immune responses, it remains a challenge to specifically target intra-tumoral Tregs. We provide a comprehensive review of distinct mechanistic links and pathways involved in regulation of Treg metabolism under the prevailing conditions within the tumour. We also describe how these Tregs differ from the ones in the periphery, and from conventional T cells in the tumour. Targeting pathways responsible for adaptation of Tregs in the tumour microenvironment improves anti-tumour immunity in preclinical models. This may provide alternative therapies aiming at reducing immune suppression in the tumour.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Treg; Metabolism; Nutrient depletion; Hypoxia; Acidity; Oxidative stress |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 17 Jan 2023 11:30 |
| Last Modified: | 17 Jan 2023 11:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47449 |
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