Agubata, Chukwuma O. and Mbaoji, Cynthia C. and Nzekwe, Ifeanyi T. and Saldias, Cesar and Diaz Diaz, David (2021) Biohydrogel Based on Dynamic Covalent Bonds for Wound Healing Applications. APPLIED SCIENCES-BASEL, 11 (15): 6945. ISSN , 2076-3417
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In this work, a biohydrogel based on alginate and dynamic covalent B-O bonds, and derived composites, has been evaluated for wound healing applications. In particular, a phenylboronic acid-alginate (PBA-Alg) complex was synthesized by coupling 3-aminophenylboronic acid onto alginate, and used to prepare varied concentrations of hydrogels and silicate-based nanocomposites in PBS. The resulting hydrogels were characterized in terms of interfacial tension, moisture uptake and loss, interaction with fresh acid-soluble collagen, self-healing ability, effects on blood clotting and wound healing. The interfacial tension between the hydrogels and biorelevant fluids was low and moisture loss of 55-60% was evident without uptake from the environment. The components of the hydrogels and their mixtures with collagen were found to be compatible. These hydrogels showed efficient self-healing and thixotropic behavior, and the animals in the treatment groups displayed blood clotting times between 9.1 min and 10.7 min. In contrast, the composites showed much longer or shorter clotting times depending on the silicate content. A significant improvement in wound healing was observed in 3% w/v PBA-Alg formulations. Overall, the PBA-Alg hydrogels exhibit self-healing dynamic covalent interactions and may be useful in dressings for incision wounds.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHENYLBORONIC ACID; HYDROGELS; NANOCOMPOSITES; dynamic covalent bond; boron; hydrogel; alginate; self-healing; nanocomposite; blood clotting; wound healing |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 09:51 |
| Last Modified: | 14 Sep 2022 09:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47459 |
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