Piszczatowska, Katarzyna and Czerwaty, Katarzyna and Cyran, Anna M. and Fiedler, Mathias and Ludwig, Nils and Brzost, Jacek and Szczepanski, Miroslaw J. (2021) The Emerging Role of Small Extracellular Vesicles in Inflammatory Airway Diseases. DIAGNOSTICS, 11 (2): 222. ISSN 2075-4418
Full text not available from this repository. (Request a copy)Abstract
Extracellular vesicles (EVs) are produced and released by all cells and are present in all body fluids. They exist in a variety of sizes, however, small extracellular vesicles (sEVs), the EV subset with a size range from 30 to 150 nm, are of current interest. By transporting a complex cargo that includes genetic material, proteins, lipids, and signaling molecules, sEVs can alter the state of recipient cells. The role of sEVs in mediating inflammatory processes and responses of the immune system is well-documented, and adds another layer of complexity to our understanding of frequent diseases, including chronic rhinosinusitis (CRS), asthma, chronic obstructive pulmonary disease (COPD), and upper airway infections. In these diseases, two aspects of sEV biology are of particular interest: (1) sEVs might be involved in the etiopathogenesis of inflammatory airway diseases, and might emerge as attractive therapeutic targets, and (2) sEVs might be of diagnostic or prognostic relevance. The purpose of this review is to outline the biological functions of sEVs and their capacity to both augment and attenuate inflammation and immune response in the context of pathogen invasion, CRS, asthma, and COPD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-DERIVED EXOSOMES; BRONCHOALVEOLAR LAVAGE FLUID; HUMAN MIDDLE-EAR; CHRONIC RHINOSINUSITIS; MEMBRANE-VESICLES; NASAL POLYPS; T-CELLS; SECRETION; BIOGENESIS; RELEASE; small extracellular vesicles; exosomes; inflammatory airway diseases; chronic rhinosinusitis; otitis media; lung diseases; bronchial diseases; inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 17 Jan 2023 12:12 |
| Last Modified: | 17 Jan 2023 12:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47483 |
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