Dempfle, Carl-Erik and Koscielny, Juergen and Lindhoff-Last, Edelgard and Linnemann, Birgit and Bux-Gewehr, Irene and Kappert, Guenther and Scholz, Ute and Kropff, Stefan and Eberle, Sonja and Bramlage, Peter and Heinken, Andreas (2021) Fondaparinux Pre-, Peri-, and/or Postpartum for the Prophylaxis/Treatment of Venous Thromboembolism (FondaPPP). CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 27: 1076029621. ISSN 1076-0296, 1938-2723
Full text not available from this repository. (Request a copy)Abstract
We analyzed data for women who received fondaparinux for >= 7 days during pregnancy. The study retrospectively included women who received fondaparinux pre-, peri- and/or postpartum for >= 7 days for prophylaxis/venous thromboembolism (VTE) treatment at German specialist centers (2004-2010). Data on pregnancy, VTE risk factors, anticoagulant treatment, pregnancy outcome and adverse events were extracted from medical records. 120 women (mean age 31.5 years) were included. Among 84 women with prior pregnancies, 41.0% had >= 1 abortion. Anticoagulation was indicated for prophylaxis in 92.5% cases, including 82.5% women with an elevated VTE risk (82.8% thrombophilia, 34.2% VTE history). All women received low-molecular-weight heparin (LMWH) as first-line therapy; 3 also unfractionated heparin. Treatment changed to fondaparinux, due to heparin allergy (41.7%) or heparin-induced thrombocytopenia (10.0%). Fondaparinux was generally well tolerated. Adverse events included bleeding events (n = 5), abortion (n = 2), premature births (n = 2), stillbirth (n = 1), arrested labors (n = 2), injection site erythema (n = 4) and unspecified drug hypersensitivity (n = 6). No VTE events or increased liver enzymes occurred during treatment. In this retrospective study, fondaparinux was effective and well tolerated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MOLECULAR-WEIGHT HEPARIN; HIP-REPLACEMENT SURGERY; POSTOPERATIVE FONDAPARINUX; INDUCED THROMBOCYTOPENIA; TRANSPLACENTAL PASSAGE; PREGNANT-WOMAN; THROMBOPROPHYLAXIS; INTOLERANCE; ENOXAPARIN; PREVENTION; fondaparinux; pregnancy; venous thromboembolism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2022 06:23 |
| Last Modified: | 16 Sep 2022 06:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47490 |
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