Denzinger, Markus and Held, Manuel and Amr, Amro and Krauss, Sabrina and Bender, Dominik and Daigeler, Adrien and Wenger, Andrea (2021) The Influence of Topically Administered Heparin on Peripheral Microcirculation of the Skin: A Double-Blind, Randomized, Controlled Preliminary Study on 50 Healthy Subjects. JOURNAL OF RECONSTRUCTIVE MICROSURGERY, 37 (08). pp. 694-703. ISSN 0743-684X, 1098-8947
Full text not available from this repository. (Request a copy)Abstract
Background Venous thrombosis is the most common cause of flap failure in the first days after surgery. Although heparin is one of the most important antithrombotic substances and is implemented in the therapy of various diseases, there are only a few studies addressing its topical administration in the field of flap surgery. Especially, very little is known about the effects of topical heparin and its impact on microcirculation. In this study we evaluated to what extent topically administered heparin influences skin microcirculation (capillary venous oxygen saturation SO2, blood filling of microvessels, blood flow, and velocity) in healthy subjects. Methods Skin perfusion parameters on the forearm were measured with the O2C device in a double-blinded, controlled, and randomized study with 50 healthy subjects after administration of heparin ointment in three different concentrations and a control ointment (dexpanthenol). Results Topically administrated heparin slightly increased SO2 (max. 187285 SD or standard deviation % vs. 145 +/- 129 SD %), flow (max. 264 +/- 427 SD % vs. 151.74 +/- 111 SD %), and velocity (max. 153 +/- 149 SD % vs. 122 +/- 56 SD %) after an incubation time of 60minutes in comparison to control. No statistically significant difference could be detected regarding heparin concentration. Conclusion As a first important step in possible future implementing of heparin as a topical administration in flap surgery, our data-although not statistically significant-indicate that heparin can improve microcirculation (SO2, flow) in healthy subjects. Nevertheless, further research in subjects with impaired microcirculation is necessary.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; heparin; microcirculation; blood flow; free flaps; O2C; perfusion |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2022 06:33 |
| Last Modified: | 16 Sep 2022 06:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47497 |
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