Aschauer-Wallner, Stephanie and Leis, Stefan and Bogdahn, Ulrich and Johannesen, Siw and Couillard-Despres, Sebastien and Aigner, Ludwig (2021) Granulocyte colony-stimulating factor in traumatic spinal cord injury. DRUG DISCOVERY TODAY, 26 (7). pp. 1642-1655. ISSN 1359-6446, 1878-5832
Full text not available from this repository. (Request a copy)Abstract
Granulocyte colony-stimulating factor (G-CSF) is a cytokine used in pharmaceutical preparations for the treatment of chemotherapy induced neutropenia. Evidence from experimental studies indicates that G-CSF exerts relevant activities in the central nervous system (CNS) in particular after lesions. In acute, subacute, and chronic CNS lesions, G-CSF appears to have strong anti-inflammatory, antiapoptotic, antioxidative, myelin-protective, and axon-regenerative activities. Additional effects result in the stimulation of angiogenesis and neurogenesis as well as in bone marrow stem cell mobilization to the CNS. There are emerging preclinical and clinical data indicating that G-CSF is a safe and effective drug for the treatment of acute and chronic traumatic spinal cord injury (tSCI), which we summarize in this review.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR G-CSF; AMYOTROPHIC-LATERAL-SCLEROSIS; PROMOTES FUNCTIONAL RECOVERY; STEM-CELL MOBILIZATION; NERVOUS-SYSTEM INJURY; MARROW-DERIVED CELLS; CLINICAL-TRIALS; ICCP PANEL; NEUROPROTECTIVE THERAPY; SECONDARY INJURY; Traumatic SCI; SCI treatment; G-CSF; Neuroregeneration; Orphan diseases |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 17 Jan 2023 12:16 |
| Last Modified: | 17 Jan 2023 12:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47501 |
Actions (login required)
 |
View Item |
