Buchbender, Mayte and Fehlhofer, Jakob and Proff, Peter and Moest, Tobias and Ries, Jutta and Hannig, Matthias and Neurath, Markus F. and Gund, Madline and Atreya, Raja and Kesting, Marco (2022) Expression of inflammatory mediators in biofilm samples and clinical association in inflammatory bowel disease patients-a preliminary study. CLINICAL ORAL INVESTIGATIONS, 26 (2). pp. 1217-1228. ISSN 1432-6981, 1436-3771
Full text not available from this repository. (Request a copy)Abstract
Objectives Inflammatory bowel disease (IBD) has multiple impacts on soft and hard tissues in the oral cavity. The aim of this study was to analyze the expression of cytokines in biofilm samples from patients suffering from IBD and compare them to healthy patients. It was hypothesized that different cytokine expression levels and clinical associations might be drawn. Material and methods A total of 56 biofilm samples from three different patient cohorts (group 0 = healthy, HC n = 30; group 1 = Crohn's disease, CD, n = 19; group 2 = ulcerative colitis, UC, n = 7) were examined for the expression levels of the cytokine interleukins IL-2, -6, and -10; matrix metalloproteinases 7 and 9; and surface antigens CD90/CD11a by quantitative real-time PCR and according to clinical parameters (plaque index, BOP, PD, DMFT, CAL). Relative gene expression was determined using the increment increment CT method. Results The mean BOP values (p = 0.001) and PD (p = 0.000) were significantly higher in the CD group compared to controls. Expression of IL-10 was significantly higher in the CD (p = 0.004) and UC groups (p = 0.022). Expression of MMP-7 was significantly higher in the CD group (p = 0.032). IBD patients treated with TNF inhibitors (p = 0.007) or other immunosuppressants (p = 0.014) showed significant overexpression of IL-10 compared to controls. Conclusion Different expression levels of IL-10 and MMP-7 were detected in plaque samples from IBD patients. As only BOP was significantly increased, we conclude that no clinical impairment of periodontal tissue occurred in IBD patients. Clinical trial registration The study is registered at the German clinical trial registry (DRKS00022956).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GINGIVAL CREVICULAR FLUID; CROHNS-DISEASE; CYTOKINES; PREVALENCE; INFLIXIMAB; MANAGEMENT; DIAGNOSIS; SMOKING; SALIVA; MANIFESTATIONS; Crohn's disease; Ulcerative colitis; Cytokine expression; Oral biofilm; Periodontitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2022 06:51 |
| Last Modified: | 16 Sep 2022 06:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47513 |
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