Martin-Montes, Alvaro and Kolodova, Kristina and Marin, Clotilde and Jose Rosales-Lombardo, Maria and Sanchez-Moreno, Manuel and de Andres-Gordo, Lucia and Cano, Carmen and Campayo, Lucrecia and Gomez-Munoz, Alberto and Sanz, Ana M. and Yunta, Maria J. R. (2021) In vitro Leishmanicidal and Trypanosomicidal Properties of Imidazole-Containing Azine and Benzoazine Derivatives. CHEMMEDCHEM, 16 (23). pp. 3600-3614. ISSN 1860-7179, 1860-7187
Full text not available from this repository. (Request a copy)Abstract
Leishmaniasis and Chagas diseases are two of the most important parasitic diseases in the world. Both belong to the category of Neglected Tropical Diseases, and they cannot be prevented by vaccination. Their treatments are founded in outdated drugs that possess many pernicious side-effects and they're not easy to administer. With the aim of discovering new compounds that could serve as anti-trypanosomal drugs, an antiparasitic study of a synthetic compound family has been conducted. A series of new 1,4-bis(alkylamino)- and 1-alkylamino-4-chloroazine and benzoazine derivatives 1-4 containing imidazole rings have been synthesized and identified. Their structures showed a possible interest based on previous work. Their in vitro anti-Leishmania infantum, anti-L. braziliensis, anti-L. donovani and anti-T. cruzi activity were tested, as well as the inhibition of Fe-SOD enzymes. It was found that some of them exhibited quite relevant values indicative of being worthy of future more detailed studies, as most of them showed activity to more than only one parasite species, especially compound 3 c was active for the three studied Leishmania species and also for T. cruzi, which is a very interesting trait as it covers a wide spectrum.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHAGAS-DISEASE REACTIVATION; IRON SUPEROXIDE-DISMUTASE; SOD INHIBITORS; CHRONIC PHASES; CRUZI; DISCOVERY; INFANTUM; PATIENT; GROWTH; BEHAVE; Azines and benzoazines; imidazole; in vitro trypanosomicidal and leishmanicidal activity; Fe-SOD inhibition |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2022 06:53 |
| Last Modified: | 16 Sep 2022 06:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47515 |
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