Lelas, Antonela and Greinix, Hildegard Theresia and Wolff, Daniel and Eissner, Gunther and Pavletic, Steven Zivko and Pulanic, Drazen (2021) Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease. FRONTIERS IN IMMUNOLOGY, 12: 676756. ISSN 1664-3224
Full text not available from this repository. (Request a copy)Abstract
Chronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeutic strategy, thus reducing prevalence and severity of the disease among long-term survivors of alloHSCT. Inflammation, endothelial injury, and endothelial dysfunction are involved in cGvHD development. Altered levels of acute phase reactants have shown a strong correlation with the activity of several immune mediated disorders and are routinely used in clinical practice. Since elevated von Willebrand factor (VWF) and factor VIII (FVIII) levels have been described as acute phase reactants that may indicate endothelial dysfunction and inflammation in different settings, including chronic autoimmune diseases, they could serve as potential candidate biomarkers of cGvHD. In this review we focused on reported data regarding VWF and FVIII as well as other markers of inflammation and endothelial dysfunction, evaluating their potential role in cGvHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VONWILLEBRAND-FACTOR; TRANSPLANTATION; ANTIGEN; BLOOD; endothelial dysfunction; inflammation; factor VIII; Von Willeband factor; chronic graft-versus-host disease (cGvHD); allogeneic hematopoietic stem cell transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 Jan 2023 05:25 |
| Last Modified: | 18 Jan 2023 05:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47518 |
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