Wang, Haichuan and Calvisi, Diego F. and Chen, Xin (2021) Organoids for the Study of Liver Cancer. SEMINARS IN LIVER DISEASE, 41 (01). pp. 19-27. ISSN 0272-8087, 1098-8971
Full text not available from this repository. (Request a copy)Abstract
Liver cancer is the second most lethal malignancy worldwide. Cell lines and murine models are the most common tools for modeling human liver carcinogenesis. Most recently, organoids with a three-dimensional structure derived from primary tissues or cells have been applied to liver cancer research. Organoids can be generated from induced pluripotent stem cells, embryonic or adult, healthy or diseased tissues. In particular, liver organoids have been widely employed in mechanistic studies aimed at delineating the molecular pathways responsible for hepatocarcinogenesis. The introduction of clustered regularly interspaced palindromic repeats (CRISPR)-associated protein 9 (Cas9) and microengineered miniorganoid technologies into liver organoids for cancer study has significantly accelerated these investigations. Translational advances have been made by utilizing liver tumor organoids for anticancer drug screening, biobanking, omics profiling, and biomarker discovery. This review summarizes the latest advances and the remaining challenges in the use of organoid models for the study of liver cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | organoids; primary liver cancer; basic research; translational science |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 Jan 2023 05:42 |
| Last Modified: | 18 Jan 2023 05:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47539 |
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