Gergs, Ulrich and Buxel, Maren L. and Bresinsky, Merlin and Kirchhefer, Uwe and Fehse, Charlotte and Horing, Carina and Hofmann, Britt and Marusakova, Margareta and Cinakova, Aneta and Schwarz, Rebecca and Pockes, Steffen and Neumann, Joachim (2021) Cardiac Effects of Novel Histamine H-2 Receptor Agonists. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 379 (3). pp. 223-234. ISSN 0022-3565, 1521-0103
Full text not available from this repository. (Request a copy)Abstract
In an integrative approach, we studied cardiac effects of recently published novel H-2 receptor agonists in the heart of mice that overexpress the human H-2 receptor (H-2-TG mice) and littermate wild type (WT) control mice and in isolated electrically driven muscle preparations from patients undergoing cardiac surgery. Under our experimental conditions, the H-2 receptor agonists UR-Po563, UR-MB-158, and UR-MB-159 increased force of contraction in left atrium from H-2-TG mice with pEC50 values of 8.27, 9.38, and 8.28, respectively, but not in WT mice. Likewise, UR-Po563, UR-MB-158, and UR-MB-159 increased the beating rate in right atrium from H-2-TG mice with pEC(50) values of 9.01, 9.24, and 7.91, respectively, but not from WT mice. These effects could be antagonized by famotidine, a H-2 receptor antagonist. UR-Po563 (1 mu M) increased force of contraction in Langendorff-perfused hearts from H-2-TG but not WT mice. Similarly, UR-Po563, UR-MB-158, or UR-MB-159 increased the left ventricular ejection fraction in echocardiography of H-2-TG mice. Finally, UR-Po563 increased force of contraction in isolated human right atrial muscle strips. The contractile effects of UR-Po563 in H-2-TG mice were accompanied by an increase in the phosphorylation state of phospholamban. In summary, we report here three recently developed agonists functionally stimulating human cardiac H-2 receptors in vitro and in vivo. We speculate that these compounds might be of some merit to treat neurologic disorders if their cardiac effects are blocked by concomitantly applied receptor antagonists that cannot pass through the blood-brain barrier or might be useful to treat congestive heart failure in patients. SIGNIFICANCE STATEMENT Recently, a new generation of histamine H-2 receptor (H2R) agonists has been developed as possible treatment option for Alzheimer's disease. Here, possible cardiac (side) effects of these novel H2R agonists have been evaluated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEART-FAILURE; RECEPTOR ANTAGONIST; ACHE INHIBITOR; AMTHAMINE; PHOSPHORYLATION; OVEREXPRESSION; IDENTIFICATION; PHOSPHOLAMBAN; STIMULATION; DIZOCILPINE; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2022 11:23 |
| Last Modified: | 16 Sep 2022 11:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47562 |
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