Rebs, Sabine and Beier, Jakob and Argyriou, Loukas and Schill, Tillmann and Hasenfuss, Gerd and Vollmann, Dirk and Sossalla, Samuel and Streckfuss-Boemeke, Katrin (2021) Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy. STEM CELL RESEARCH, 53: 102263. ISSN 1873-5061, 1876-7753
Full text not available from this repository. (Request a copy)Abstract
Arrhythmia-induced cardiomyopathy (AIC) is characterized by left-ventricular systolic dysfunction caused by persistent arrhythmia. To date, genetic or pathological drivers causing AIC remain unknown. Here, we generated induced pluripotent stem cells (iPSCs) from an AIC patient. The AIC-iPSCs exhibited full pluripotency and differentiation characteristics and maintained a normal karyotype after reprogramming. The AIC-iPSCs differentiated into functional beating AIC-iPSCcardiomyocytes (CMs), which represents the cell-type of interest to study molecular, genetic and functional aspects of AIC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2022 15:37 |
| Last Modified: | 16 Sep 2022 15:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47565 |
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