Kuo, Selena Z. and Dettmer, Katja and Annavajhala, Medini K. and Chong, David H. and Uhlemann, Anne-Catrin and Abrams, Julian A. and Oefner, Peter J. and Freedberg, Daniel E. (2021) Associations between urinary 3-indoxyl sulfate, a gut microbiome-derived biomarker, and patient outcomes after intensive care unit admission. JOURNAL OF CRITICAL CARE, 63. pp. 15-21. ISSN 0883-9441, 1557-8615
Full text not available from this repository. (Request a copy)Abstract
Purpose: 3-indoxyl sulfate (3-IS) is an indole metabolism byproduct produced by commensal gut bacteria and excreted in the urine; low urinary 3-IS has been associated with increased mortality in bone marrow transplant recipients. This study investigated urinary 3-IS and patient outcomes in the ICU. Materials and methods: Prospective study that collected urine samples, rectal swabs, and clinical data on 78 adult ICU patients at admission and again 72 h later. Urine was analyzed for 3-IS by mass spectrometry. Results: Median urinary 3-IS levels were 17.1 mu mol/mmol creatinine (IQR 9.5 to 26.2) at admission and 15.6 (IQR 4.2 to 30.7) 72 h later. 22% of patients had low 3-IS (<= 6.9 mu mol/mmol) on ICU admission and 28% after 72 h. Low 3-IS at 72 h was associated with fewer ICU-free days (22.5 low versus 26 high, p = 0.03) and with death during one year of follow-up (36% low versus 9% high 3-IS, p < 0.01); there was no detectable difference in 30-day mor-tality (18% low versus 5% high, p = 0.07). Conclusions: Low urinary 3-IS level 72 h after ICU admission was associated with fewer ICU-free days and with increased one-year but not 30-day mortality. Further studies should investigate urinary 3-IS as an ICU biomarker. (c) 2021 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MORTALITY; MULTICENTER; PROBIOTICS; DIVERSITY; INDOXYL; INDOLE; 3-indoxyl sulfate; Microbiome; Biomarker; Intensive care |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2022 16:42 |
| Last Modified: | 16 Sep 2022 16:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47577 |
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