Petersen, Anders O. and Jokinen, Martta and Plichta, Damian R. and Liebisch, Gerhard and Gronwald, Wolfram and Dettmer, Katja and Oefner, Peter J. and Vlamakis, Hera and Chung, Daniel C. and Ranki, Annamari and Xavier, Ramnik J. (2021) Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 148 (3). pp. 876-888. ISSN 0091-6749, 1097-6825
Full text not available from this repository. (Request a copy)Abstract
Background: Gastrointestinal dysfunction is a frequent and disabling manifestation of autoimmune polyendocrine syndrome type 1 (APS-1), a rare monogenic multiorgan autoimmune disease caused by the loss of central AIREcontrolled immune tolerance. Objectives: This study aimed to understand the role of the gut microbiome in APS-1 symptoms and potentially alleviate common gastrointestinal symptoms by probiotic intervention. Methods: This study characterized the fecal microbiomes of 28 patients with APS-1 and searched for associations with gastrointestinal symptoms, circulating anti-cytokine autoantibodies, and tryptophan-related metabolites. Additionally, daily doses of the probiotic Lactobacillus rhamnosus GG were administered for 3 months. Results: Of 581 metagenomic operational taxonomic units (mOTUs) characterized in total, 14 were significantly associated with patients with APS-1 compared with healthy controls, with 6 mOTUs depleted and 8 enriched in patients with APS-1. Four overabundant mOTUs were significantly associated with severity of constipation. Phylogenetically conserved microbial associations with autoantibodies against cytokines were observed. After the 3-month intervention with the probiotic L rhamnosus GG, a subset of gastrointestinal symptoms were alleviated. L rhamnosus GG abundance was increased postintervention and corresponded with decreased abundances of Alistipes onderdonkii and Collinsella aerofaciens, 2 species positively associated with severity of diarrhea in patients with APS-1. Conclusions: The APS-1 microbiome correlates with several APS-1 symptoms, some of which are alleviated after a 3-month L rhamnosus GG intervention. Autoantibodies against cytokines appear to shape the gut microbiome by positively correlating with a taxonomically consistent group of bacteria. (J Allergy Clin Immunol 2021;148:876-88.)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC MUCOCUTANEOUS CANDIDIASIS; RECEPTOR; METABOLITES; INDUCTION; CELLS; APS-1; APECED; autoimmunity; autoantibody; cytokine; chemokine; microbiome; Lactobacillus rhamnosus GG; tryptophan; GABA |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Sep 2022 12:37 |
| Last Modified: | 20 Sep 2022 12:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47665 |
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