Eisermann, Philip and Rubbenstroth, Dennis and Cadar, Daniel and Thome-Bolduan, Corinna and Eggert, Petra and Schlaphof, Alexander and Leypoldt, Frank and Stangel, Martin and Fortwaengler, Thorsten and Hoffmann, Florian and Osterman, Andreas and Zange, Sabine and Niller, Hans-Helmut and Angstwurm, Klemens and Poertner, Kirsten and Frank, Christina and Wilking, Hendrik and Beer, Martin and Schmidt-Chanasit, Jonas and Tappe, Dennis (2021) Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018-2020. EMERGING INFECTIOUS DISEASES, 27 (5). pp. 1371-1379. ISSN 1080-6040, 1080-6059
Full text not available from this repository. (Request a copy)Abstract
Human bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of encephalitis cases in Germany during 2018-2020 by using a serologic testing scheme applied along proposed graded case definitions for VSBV-1, BoDV-1, and unspecified bornavirus encephalitis. Of 103 encephalitis cases of unknown etiology, 4 bornavirus infections were detected serologically. One chronic case was caused by VSBV-1 after occupational-related contact of a person with exotic squirrels, and 3 acute cases were caused by BoDV-1 in virus-endemic areas. All 4 case-patients died. Bornavirus etiology could be confirmed by molecular methods. Serologic testing for these cases was virus specific, discriminatory, and a practical diagnostic option for living patients if no brain tissue samples are available. This testing should be guided by clinical and epidemiologic suspicions, such as residence in virus-endemic areas and animal exposure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE VIRUS |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 06:37 |
| Last Modified: | 14 Sep 2022 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47703 |
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